A new frontier in Drug Design

We aim to revolutionize the way diseases are diagnosed and treated.


The Team

Rafael Bottos



Graduated in Mechanical Engineering at UFSC and Alumni of Harvard Business School. Researcher at the Fraunhofer Institute in Germany from 2005 to 2008. MIT Advisor in Brazil, Endeavor Global Member, Award Winning “Entrepreneur of the Year”- Brazil 2014 (Exame PME), Founded Welle Laser in 2008, ExactSales in 2015, Vesper Ventures in 2016 and joined Aptah BioSciences in 2020. He currently works as CEO of Aptah BioSciences SA and is attending specialization courses in molecular biology (genetics and biochemistry) at Harvard Medical School.

In Short

Aptah is a biotech company that aims to support medical advancements by introducing innovative technologies into the drug discovery process. 

Through Aptah's technology we are able to modulate the spliceosome machinery and thus, the pre-mRNA, which ensures the precise control of the transcription step and modulation of specific gene expression -not only silencing, but also editing the pre-mRNA by hacking the spliceosome machinery.

Get in touch to learn more.

Lab Experiment

Our Technology

Aptah is focused on treating and diagnosing tauopathy diseases – diseases associated with protein TAU expression. Microtubule-Associated Protein Tau (MAPT) or TAU, is thought to be a major contributor or cause of certain diseases, known as tauopathies, that are characterized by the deposition of abnormal tau protein inside cells, such as neurons and glial in the brain and breast cells. These disorders include Alzheimer’s disease (AD), Progressive Supranuclear Palsy (PSP), some forms of frontotemporal degeneration (FTD), Glioblastoma, Neuroblastoma and Breast Cancer.


Aptah antisense therapy controls TAU expression inside cells, bringing it to a normal level, which stabilizes the cell’s metabolism. Therefore, we are able to reduce its oxidation, inflammation and reproduction rate. 

Click below to learn more about the technology behind Aptah, or get in touch to set up a meeting with us.

Get in Touch

Aptah Biosciences
930 Brittan Avenue
San Carlos, CA 94070


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